Title: Somatic mutation in peripheral blood lymphocytes among Metro Manila residents: Indicator of exposure to environmental pollution
Authors: Teresa Yulo-Nazarea, Ma. Lucia C. Cobar, Marla A. Endriga, Efren J. Sta. Maria, Alejandro Q. Nato, Jr., Javier M. Eduardo, and Romy Dy
Technical Report Institution: Philippine Nuclear Research Institute
Catalogued by: International Nuclear Information System
Publication Date: 1994
Volume: 26
Issue: 13
Technical Report Source: PNRI-C(HP)--94007
Technical Report Reference Number: 26046988
Abstract: Metro Manila is ranked as one of the world's most polluted cities where air quality levels are 2-3 times higher than the levels set by WHO. Development of diseases could be alleviated if early warning signs as occurrence of gene nmtatiens are detected early enough. The adapted hypoxanthine guanine phosphoribosyl transferase (HGPRT) mutation assay measures the degree of mutation on the HGPRT gene and allows rapid evaluation of the occurrence of mutation in an individual exposed to radiation or mutagens within six months after exposure. The objective of the project is to (1) assay exposure of Metro Manila residents exposed to environmental pollution, (2) determine population groups significantly affected by pollutants and (3) construct an environmental baseline HGPRT mutation data bank specific to area in Metro Manila. A composite table of personal information of donors against mutation index in two barangays in Valenzuela is presented. About 30% of the total samples are shown to have mutation index greater than 0.5. So far, the data show a slightly higher mutation rate among donors who are smokers with more than 5 hours outdoor exposure to pollutants per day than the corresponding class of nonsmokers.
Citation PDF URL: http://www.iaea.org/inis/collection/NCLCollectionStore/_Public/26/046/26046988.pdf